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In a double-blind study carisoprodol was found to be superior to diazepam in the treatment of patients with at least moderately severe low back pain and spasm of no longer than seven days duration.
The firsf RCT (80 people) found that csrisoprodol significantly increased overall improvement compared with diazepam but found no significant difference in pain at 7 days (improvement rated as vrey good or excellent; 70% with carisoprodol v 45% with diazepam; pain on 100 mm visual analogue scale: 58 mm with carisoprodol v 48 mm with diazepam; P values not reported in the review)
Carisoprodol was more effective than diazepam in overall relief of acute LBP (70% vs. 45%)
In this head-to-head trial, the overall incidence of adverse reactions was higher in the diazepam treated group but was not of statistical significance.

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Why is this medication prescribed?
Soma (carisoprodol), a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?
Carisoprodol comes as a tablet to take by mouth. It usually is taken three times daily and at bedtime. It may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take carisoprodol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
What special precautions should I follow?
Before taking carisoprodol,
tell your doctor and pharmacist if you are allergic to carisoprodol, meprobamate (Equanil, Meprospan, Miltown, Neuramate), or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially medications for allergies, coughs, or colds; muscle relaxants; sedatives; sleeping pills; tranquilizers; and vitamins.
tell your doctor if you have or have ever had kidney or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking carisoprodol, call your doctor.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how carisoprodol affects you.
remember that alcohol can add to the drowsiness caused by this drug.
What special dietary instructions should I follow?
Carisoprodol may cause an upset stomach. Take carisoprodol with food or milk.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Carisoprodol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
drowsiness
dizziness
clumsiness
headache
fast heart rate
upset stomach
vomiting
skin rash
If you experience any of the following symptoms, call your doctor immediately:
difficulty breathing
fever
weakness
burning in the eyes
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from moisture and heat (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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