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Celebrex (Celecoxib)
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Celecoxib is used for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not prevent the progression of either type of arthritis. It reduces only the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who have not had their colons removed. Celebrex also is approved for the relief of acute pain and the pain of menstrual cramps (primary dysmenorrhea).
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The lowest effective dose should be used for each patient. For the management of osteoarthritis, the dose usually is 100 mg twice daily or 200 mg as a single dose. For rheumatoid arthritis, the dose usually is 100 or 200 mg twice daily. For acute pain or menstrual cramps, the dose is 400 mg as a single dose on the first day, followed by an additional 200 mg if needed, then 200mg twice daily as needed. For FAP, the recommended dose is 400 mg twice daily.
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Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes the pain, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in lower concentrations of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood. NSAIDs have been found to prevent the formation and reduce the size of polyps in patients with the genetic disease, familial adenomatous polyposis (FAP). In FAP, patients develop large numbers of polyps in their colons, and the polyps invariably become malignant. The only cure of FAP requires removal of the entire colon. Celecoxib is approved as an adjunctive (secondary) treatment among patients with FAP. The cramping and pain during menstrual periods is due to prostaglandins, and blocking the production of prostaglandins with celecoxib reduces the cramps and pain.
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Celebrex (Celecoxib)
Drug Uses
Celecoxib is used for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not prevent the progression of either type of arthritis. It reduces only the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who have not had their colons removed. Celebrex also is approved for the relief of acute pain and the pain of menstrual cramps (primary dysmenorrhea).
How Taken
The lowest effective dose should be used for each patient. For the management of osteoarthritis, the dose usually is 100 mg twice daily or 200 mg as a single dose. For rheumatoid arthritis, the dose usually is 100 or 200 mg twice daily. For acute pain or menstrual cramps, the dose is 400 mg as a single dose on the first day, followed by an additional 200 mg if needed, then 200mg twice daily as needed. For FAP, the recommended dose is 400 mg twice daily.
Drug Class and Mechanism
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes the pain, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in lower concentrations of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood. NSAIDs have been found to prevent the formation and reduce the size of polyps in patients with the genetic disease, familial adenomatous polyposis (FAP). In FAP, patients develop large numbers of polyps in their colons, and the polyps invariably become malignant. The only cure of FAP requires removal of the entire colon. Celecoxib is approved as an adjunctive (secondary) treatment among patients with FAP. The cramping and pain during menstrual periods is due to prostaglandins, and blocking the production of prostaglandins with celecoxib reduces the cramps and pain.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless your doctor directs otherwise.
Storage
Capsules should be stored at 25 degrees C (77 degrees F). It is okay for brief periods in temperatures between 15-30 degrees C (59-86 degrees F).
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Drug Name
Celebrex (Celecoxib)
Drug Uses
Celecoxib is used for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not prevent the progression of either type of arthritis. It reduces only the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who have not had their colons removed. Celebrex also is approved for the relief of acute pain and the pain of menstrual cramps (primary dysmenorrhea).
How Taken
The lowest effective dose should be used for each patient. For the management of osteoarthritis, the dose usually is 100 mg twice daily or 200 mg as a single dose. For rheumatoid arthritis, the dose usually is 100 or 200 mg twice daily. For acute pain or menstrual cramps, the dose is 400 mg as a single dose on the first day, followed by an additional 200 mg if needed, then 200mg twice daily as needed. For FAP, the recommended dose is 400 mg twice daily.
Drug Class and Mechanism
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes the pain, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in lower concentrations of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood. NSAIDs have been found to prevent the formation and reduce the size of polyps in patients with the genetic disease, familial adenomatous polyposis (FAP). In FAP, patients develop large numbers of polyps in their colons, and the polyps invariably become malignant. The only cure of FAP requires removal of the entire colon. Celecoxib is approved as an adjunctive (secondary) treatment among patients with FAP. The cramping and pain during menstrual periods is due to prostaglandins, and blocking the production of prostaglandins with celecoxib reduces the cramps and pain.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless your doctor directs otherwise.
Storage
Capsules should be stored at 25 degrees C (77 degrees F). It is okay for brief periods in temperatures between 15-30 degrees C (59-86 degrees F).
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Nothing like a new use for aging or troubled drugs to make a marketers day. The combination of the two Pfizer pills work through different mechanisms of action, but there is a synergistic effect that inhibits the growth of prostate cancer cells, Xi Cheng, assistant research professor at Rutgers, the State University of New Jersey, who conducted the study, tells Reuters.
The Rutgers team found that the combination of low doses of Lipitor and Celebrex had a more potent impact on tumor growth than a higher dose of either agent when used separately. The combo was administered to cultured mice tumors in order to measure the transition of early prostate cancer to its more aggressive and potentially fatal stage, according to Zheng, who adds that Pfizer played no role in study, which was funded by the NIH.
In the early stage of the disease, prostate cancer cells depend on androgen hormones, such as testosterone, to grow. Treatment involves either decreasing the production of the hormone or blocking its action. The objective of the Rutgers study was to indefinitely delay the transition to androgen-independence, prolonging the time during which the cancer would be responsive to low-toxicity, anti-hormone therapy, Reuters writes. Zheng says it appears that a cell signaling pathway for tumor cell growth is inhibited by the combination of the two compounds.
Human clinical trials are being planned. Of course, the results are unlikely to be available before Lipitor patent protection evaporates in 2010 or 2011. But the prospect of a cancer cocktail must be tantalizing, nonetheless, especially given concerns over cardiovascular side effects that have plagued Celebrex for the past few years.
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The Rutgers team found that the combination of low doses of Lipitor and Celebrex had a more potent impact on tumor growth than a higher dose of either agent when used separately. The combo was administered to cultured mice tumors in order to measure the transition of early prostate cancer to its more aggressive and potentially fatal stage, according to Zheng, who adds that Pfizer played no role in study, which was funded by the NIH.
In the early stage of the disease, prostate cancer cells depend on androgen hormones, such as testosterone, to grow. Treatment involves either decreasing the production of the hormone or blocking its action. The objective of the Rutgers study was to indefinitely delay the transition to androgen-independence, prolonging the time during which the cancer would be responsive to low-toxicity, anti-hormone therapy, Reuters writes. Zheng says it appears that a cell signaling pathway for tumor cell growth is inhibited by the combination of the two compounds.
Human clinical trials are being planned. Of course, the results are unlikely to be available before Lipitor patent protection evaporates in 2010 or 2011. But the prospect of a cancer cocktail must be tantalizing, nonetheless, especially given concerns over cardiovascular side effects that have plagued Celebrex for the past few years.
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In its third week of sales, Celebrex, Monsanto Co.s Cox-2 inhibitor for arthritis pain, generated 93,838 prescriptions nationwide, according to IMSa sales start surpassed only by Viagra in terms of top product launches. The majority of Celebrex prescriptions (67 percent) are being dispensed through chain drug stores, followed by independent pharmacies, which are dispensing 31 percent of prescriptions. The remaining business is held by food store pharmacies and mail-order prescriptions, accounting for ii percent and 1 percent of prescriptions, respectively.
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